This Safety Support Case (SSC) has been developed to support the use case “Climb and Descent” under exploratory development by the NM Lab. The SSC will be used in support of the Guidance Material being developed by EASA. \r\nThe “Climb and Descent” Sequence of the NM Lab is intended to improve the 4D trajectory calculation of flights especially during tactical phases, by better prediction of climb and descent rates with the use of Machine Learning / Deep Learning techniques.