On 4 November 2025, the flight crew of a Boeing MD-11F departing Louisville lost control of their aircraft after the left engine and pylon separated from the aircraft shortly after it rotated for takeoff. Fire ignited in both the detached engine and the left wing, the aircraft failed to gain height, and the left main landing gear impacted structures close to the airport perimeter before it crashed into buildings approximately 1,000 metres beyond it and was destroyed by fire. Pending progress with the Investigation, the aircraft operator has grounded its MD-11F fleet. FAA has issued related emergency Airworthiness Directives grounding MD-11s, MD-11Fs, and DC-10s until specified inspections and corrective actions have been performed.